3,4-Dichlorophenylacetonitrile is an intermediate used in the synthesis of SR 48968, a potent, competitive and selective non-peptide antagonist of the neurokinin A (NK2) receptor1 (1,2,3). It is also used to prepare tachykinin NK3 receptor antagonist SR 142801, (R)-N-[ 1-[3-[ 1-benzoyl-3-(3,4-dichlororphenyl)-3-piperidinyl]propyyl]-4-phenyl-4-piperidinyl-N-methyl acetamide.
參考文獻
(1) Emonds-Alt, X., et al.: Bioorg. Med. Chem. Lett., 3, 925 (1993)(2) Chen, H., et al.: Bioorg. Med. Chem. Lett., 7, 555 (1997)(3) Burkholder, T. P., et al. Bioorg. Med. Chem. Lett. 6, 951 (1996)
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